Memento

I’m not quite sure what to focus on in Memento because so much of it is so great.  First, let me just say that Christopher Nolan is a genius. The reverse chronology of the film is brilliant.  Not only is it an interesting break from the typical chronological movie, but also it emphasizes the confusion of Leonard’s memory loss.  Whenever we see a scene begin, we do not know where Leonard has come from or why he is there, just as Leonard himself is unclear as to his situation.  In an interview with journalist Anthony Kaufman, Nolan explains, “There's this weird irony, because you actually find yourself as a filmmaker in the position of the protagonist that has to trust these notes he's written himself… absolutely trust your initial instincts.”  This connection between the director and Leonard translates into a strong sense of being "lost" within the film. 

Nolan also brings up the notion of trust.  In Memento, it is impossible for Leonard to trust anyone but himself.  That’s why he only believes his own handwriting.  As a viewer, I found that I was also at a bit of loss regarding whom to trust, particularly because we only know bits and pieces of each character.  For instance, Natalie comes off as incredibly reliable at the beginning of the movie because she seems to be helping Leonard out of the goodness of her heart.  But then we learn that she sent him on a mission of vengeance and perhaps even framed Teddy for her own benefit.  We cannot tell as of yet whether Natalie is trustworthy, because just like Leonard, we have no information about her past.  I am anxiously awaiting discovering the true intentions of all of the characters and whether Leonard has killed the right man.

Source: http://www.indiewire.com/article/decade_christopher_nolan_on_memento